iM3 Catalogue - Europe - Flipbook - Page 56
iM3 - The Veterinary Dental Company
Synergy - Pure Synthetic Bone Graft
Effective Bone Graft Substitute
Perfect for dental applications. Ideal auto or allograft
Clearly evident on radiographic images, allowing
visualization of bone graft placement.
The price conscious solution for periodontal or orthopedic
bone void filling.
Innovative, Convenient Packaging
Synergy is an advanced biosynthetic bone graft comprised of calcium phosphates that occur naturally in real bone. It is a biphasic combination of
β-Tricalcium Phosphate (β -TCP) and Hydroxyapatite (HA).
Advanced Formulation - Biphasic Synergy is composed of biocompatible β-TCP and HA1 sintered together. The ratio is optimized for swift
transformation into new bone throughout the graft.
85% resorbable β -TCP
15% structurally stable HA
Balanced Remodelling - Synergy works with the body in 2 integrated phases:
Phase 1: β-TCP simultaneously resorbs as new bone is formed2, remodeling throughout the graft
Phase 2: HA microparticles slowly resorb, providing an osteoconductive scaffold
Cancellous-like, Osteoconductive Morphology - Synergy’s structure is the architectural equivalent of cancellous bone.
Interconnected porous structure encourages stem cell migration, proliferation and differentiation into osteoblasts2
Provides for an adequate flow of nutrients to enhance new bone formation3
These intelligent bioactive materials have the proven ability to stimulate bone formation.3 The β -TCP quickly releases calcium ions4 that cause
clotting and release of platelet-derived growth factors. This cascade of mineral release and blood clotting provides the perfect environment for
stimulation of bone healing.
The cancellous-like porosity and surface structure encourage inward cell migration. As the β -TCP resorbs more space is created to support
angiogenesis and bone formation1. The micro particles of HA provide a more long lasting osteoconductive structure.
Filling, bridging and/or reconstruction of non weight-bearing bony defects.
Void filling / Extraction sites
Periodontal pockets / Other bone loss
Cysts / Other osseous defects
1. Farina et al., In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs. J Mater Sci: Mater Med 19:1565-1573, 2008
2. Spivak JM, Hasharoni A. Use of hydroxyapatite in spine surgery. Eur Spine J. 10: S197-S204, 2001
3. Habibovic P, de Groot K. Osteoinductive biomaterials –properties and relevance in bone repair. J Tissue Eng Regen Med. 1: 25-32, 2007
4. Daculsi et al., Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Bio Mat Res 23:883-94,1989
Synergy Mini Vials 4 cc (8 x 0.5 cc doses)