iM3 Catalogue - Europe - Flipbook - Page 58
iM3 - The Veterinary Dental Company
Synergy - Pure Synthetic Bone Graft
Effective Bone Graft Substitute
Perfect for dental applications. Ideal auto or allograft extender.
Clearly evident on radiographic images, allowing visualization of
bone graft placement.
The price conscious solution for periodontal or orthopedic
bone void filling.
Innovative, Convenient Packaging
Synergy Mini Vials 4 cc (8 x 0.5 cc doses)
Synergy is an advanced biosynthetic bone graft comprised of
calcium phosphates that occur naturally in real bone. It is
a biphasic combination of β-Tricalcium Phosphate (β -TCP)
and Hydroxyapatite (HA).
Advanced Formulation - Biphasic Synergy is composed of
biocompatible β-TCP and HA1 sintered together. The ratio is
optimized for swift transformation into new bone throughout
85% resorbable β -TCP
15% structurally stable HA
Balanced Remodelling - Synergy works with the body in
2 integrated phases:
Phase 1: β-TCP simultaneously resorbs as new bone is
formed2, remodeling throughout the graft
Phase 2: HA microparticles slowly resorb, providing an
Cancellous-like, Osteoconductive Morphology - Synergy’s
structure is the architectural equivalent of cancellous bone.
Interconnected porous structure encourages stem cell
migration, proliferation and differentiation into osteoblasts2
Provides for an adequate flow of nutrients to enhance new
These intelligent bioactive materials have the proven ability to
stimulate bone formation.3 The β -TCP quickly releases calcium
ions4 that cause clotting and release of platelet-derived growth
factors. This cascade of mineral release and blood clotting
provides the perfect environment for stimulation of bone healing.
The cancellous-like porosity and surface structure encourage
inward cell migration. As the β -TCP resorbs more space
is created to support angiogenesis and bone formation1.
The micro particles of HA provide a more long lasting
Filling, bridging and/or reconstruction of non weight-bearing
Void filling / Extraction sites
Periodontal pockets / Other bone loss
Cysts / Other osseous defects
1. Farina et al., In vivo behaviour of two different biphasic
ceramic implanted in mandibular bone of dogs. J Mater Sci:
Mater Med 19:1565-1573, 2008
2. Spivak JM, Hasharoni A. Use of hydroxyapatite in spine
surgery. Eur Spine J. 10: S197-S204, 2001
3. Habibovic P, de Groot K. Osteoinductive biomaterials –
properties and relevance in bone repair. J Tissue Eng Regen
Med. 1: 25-32, 2007
4. Daculsi et al., Transformation of biphasic calcium phosphate
ceramics in vivo: ultrastructural and physicochemical
characterization. J Bio Mat Res 23:883-94,1989