IDRR APRIL -MAY -JUNE 2020 - Flipbook - Page 69
INTERDISCIPLINARY
MECHANISM OF ACTION
Some of the hypothetical mechanism of probiotics
action in the oral cavity includes
Direct interaction in dental plaque
• Enmeshing in securing of oral microorganisms to
proteins
• Agility on plaque evolution and on its complex
ecosystem by competing and intervening with
bacterial attachments
• Engaging in metabolism of substrate and yielding
of chemicals that inhibit oral bacteria.
Indirect probiotic actions featured are
• Modulating systemic immune function
• Effect on local immunity
• Eventuality on nonimmunologic defense
mechanisms
• Regulation of mucosal permeability
• Probiotics function as antioxidants and also
produce antioxidants
• Hamper plaque induction by neutralizing the free
electrons.
The mechanisms of probiotic action in the oral cavity
could be analogous to those described for the
intestine. Conceivable means through which
probiotics might affect oral health are summarized in
Figure below
viable for periods under storage and field conditions.
Probiotic delivery system:
They are provided in four basic forms
• Beverage or food (fruit juice)
• Prebiotic fibers
• Milkbased products
• Dried cell packages such as powder, capsule,
gelatin tablets.
PROBIOTICS AND DENTAL CARIES
The impact of oral administration of probiotics on
dental caries has been studied in several experiments.
Considering the emerging and growing body of
evidence about the role of probiotics on caries
pathogens, it has been recommended that the
operative approach in caries treatment might be
challenged by probiotic implementation with
subsequent less invasive intervention in clinical dentistry.
PROBIOTICS AND PERIODONTAL DISEASES
Orally administered probiotics could be beneficial in
the treatment of chronic Periodontitis. The presence
of periodontal pathogens could be regulated by
means of antagonistic interactions. Probiotic strains
comprised in periodontal dressings at optimal
concentration of 108 CFU/ml have been shown to
diminish the number of most frequently isolated
periodontal pathogens.
CONCLUSION
.
Features of a good probiotics:
• It should be a strain, which is capable of exerting a
beneficial effect on the host animal, e.g., elevated
growth or hindrance to disease
• It should be nonvirulent and nonpathogenic
• Preferred to be present as viable cells in large
numbers
• It should be capable of surviving and metabolizing
in the gut environment, e.g., endurance to low pH
and carbonbased acids, and should be able to
maintain genetic stability in oral microflora
• It should be stable and adept of permanently
July-August-September 2019
Probitics come up as an preventive measure for the
lessening the chances of dental caries and periodontal
diseases. The intestinal microflora indirectly helps in
the maintenance of the oral cavity and it health.
Probiotics enhance the gut flora thereby making the
periodontium healthy.
BIBLIOGRAPHY:
[1] Cho I, Blaser MJ.The human microbiome: at the interface of health and disease. Nat Rev Genet.
2012;13(14):260–13.
[2] Belkaid Y, Hand TW. Role of the microbiota in
immunity and inflammation. Cell. 2014;157:121–141.
www.idrr.in
69