ID-5184 Wonca Abstracts supplement L-Z 13-10-23 - Flipbook - Page 51
WONCA 2023 Supplement 2: WONCA 2023 abstracts (L–Z)
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Association between visit-to-visit blood pressure
variability and cardiovascular disease: comparation
among studies from clinical trial, observational and
electronic health records
Miss Mifetika Lukitasari
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University of New South Wales
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Background
Studies investigating the association between visit-to-visit blood pressure variability (BPV) and
cardiovascular disease have been conducted in different settings, such as post hoc analysis of clinical
trial, observational studies and electronic health record data. The primary aim for systematic review
and meta-analysis is to comprehensively compare the effect of visit-to-visit BPV on cardiovascular
events among studies using observational, clinical trial and electronic health record data. While
the secondary aims are to investigate the association of baseline characteristics and comorbidities
(age, gender, BMI, comorbidities: diabetes mellitus, hypertension, dyslipidaemia, smoking) BPV and
evaluating the approaches (number of visits, time interval between visits) used to estimate BPV.
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Methods
A systematic literature search will be performed in the following databases: MEDLINE (PubMed);
SCOPUS; EMBASE; CINAHL; and Web of Science. All collected studies will be screened based on
title, abstract and full text by two independent reviewers. Studies with the following criteria: (1) adult
participants aged ≥18 years; (2) measurement of BP at three or more visits on different days; (3) follow
up for outcomes of incident CVD (myocardial infarction, fatal and non-fatal coronary heart disease,
fatal and non-fatal stroke, heart failure, peripheral artery disease, atrial fibrillation; (4) events confirmed
via database or event ascertainment committee; (5) adjustment for confounders undertaken in the
design or analysis stages of the study; (6) duration of follow up three or more years; and (7) studies in
English Language. Risk of bias will be assessed using standard form. Random effects meta-analysis
and meta-regression will be applied using R.
Discussion
The comparation of three major sources of BPV data will be the major novelty of this systematic review
and meta-analysis with respective of baseline characteristics and the comorbidities into account.
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