2024 - Kidney Research Impact Report - Flipbook - Page 8
The following is a selection of published studies
where KRC sta昀昀 appeared as 昀椀rst or senior authors.
Advancing
Kidney
Disease
Research:
Scientific
Publications
2022-2023
8
The Ottawa Hospital | Kidney Research Centre
Urinary podocyte-derived large extracellular vesicles are increased in
pediatric idiopathic nephrotic syndrome: This research study demonstrated
that children with idiopathic nephrotic syndrome (characterized by urinary
excretion of large amounts of protein, leading to generalized swelling and risk
of infections and blood clotting have increased levels of large extracellular
vesicles in the urine (“EVs”. The large EVs decrease when the children are in
clinical remission, suggesting that their presence may be a marker of disease
activity.
The Proteome of Circulating Large Extracellular Vesicles in Diabetes
and Hypertension: Large extracellular vesicles (EVs) are released from
injured blood cells and are present in the circulation. This study examined the
content of large EVs isolated from the blood of mice with hypertension or
diabetes compared to healthy mice. The results show that large EVs contain
distinct protein “signatures” depending on the disease. This information could
improve our understanding of the basis for blood vessel injury in hypertension
and diabetes.
Successful Endovascular Management of Resistant Hypertension Post
Kidney Transplant: A Case Report: This case report describes a patient with
a longstanding kidney transplant who developed high blood pressure resistant
to treatment, along with transplant dysfunction. The patient was discovered to
have a serious blockage of the iliac artery on the side of the transplant that led
to retrograde perfusion of the transplant kidney from the artery on the opposte
side, causing hypertension and kidney dysfunction. The patient was treated
with balloon dilatation of the iliac artery and stent insertion, and this resulted
in normalization of blood pressure and return to normal kidney transplant
function.