20-00950 KANA EquineLeakyGutFlipbook PaperTurn optB 10-30-20 - Flipbook - Page 21
MODE OF ACTION
WHY IS THIS IMPORTANT?
Pathogenic bacteria like C. perfringens create lesions
in the small intestine that compromise the integrity
of the intestinal lining. Harmful pathogens and toxins
can then pass through the intestinal lining into the
bloodstream, resulting in intestinal inflammation and
disease. By inhibiting the growth of pathogenic bacteria,
the PB6 in CLOSTAT helps maintain a healthy microbial
balance in the horse’s digestive tract.
Clostridium perfringens
CLOSTAT®
The PB6 in CLOSTAT has been found to secrete one or
more biocidal proteins that are inhibitory towards certain
strains of pathogenic bacteria such as C. perfringens and
other equine-specific pathogens. These proteins disrupt
the membrane of bacteria, causing leakage of the cell
contents and ultimately killing the pathogenic bacteria
without harming the beneficial gut microflora.