May 2024 SOCRA Source Journal - Journal - Page 49
Figure 1. Translational Research
revealed some studies that
TNBC. Depending on the data
9.
Signal
Transducer
and
from Figure
medical 1
records,
the poorer
therapy
pathways for metastatic breast cancer.have shown STAT1 in a proActivator of Transcription 1
immune active role, in a tumour
prognosis of TNBC and their
(STAT1)
suppressor role, and as an antidisproportionate burden on
Previously,
studies
have
tumour transcription factor.
Hispanic and other medically
discovered the importance of
However, other studies have
disadvantaged groups makes
Signal Transducer and Activator
shown that STAT1 has been
it critical to identify factors
of
Transcription
1
(STAT1)
in
reported to be up-regulated in
that differentially in昀氀uence the
cancer. STAT1 belongs to a family
the late stage of breast cancer
development of this subtype
of transcription factors which
(Manavi et al. 2007).
(Figure 1). Modi昀椀able factors
transduce
signals
generated
by
such as breast
feeding
have
9 Signal Transducer and Activator of Transcription 1 (STAT1)
a wide variety of extracellular
Additionally, It was discovered
great public health signi昀椀cance,
Previously, studies have discovered the importance of Signal Transducer
and Activator
stimuli and are involved in
and reported that STAT1
which may inform and in昀氀uence
many mechanisms,
such as,to a familyregulates
of Transcription
1 help
(STAT1) in cancer.
STAT1 belongs
of transcription
factors
DNA repair
pathways
prevention
strategies to
the
regulation
of
cell
survival,
as a predictive marker for breast
close the gap in breast cancer
which transduce signals generated
by a and
wide
variety of extracellular
stimuli and are
proliferation
differentiation
in
cancer chemotherapy and
survival across racial ethnic
tissue
(Ihle 2001).
radiotherapy
resistance
(Khodarev
groups
owing to
involved
in differential
many mechanisms,nearly
suchallas,
the types
regulation
of cell survival,
proliferation
and
et al. 2004). Although, there
occurrence of breast cancer
differentiation
nearly all tissue
types of
(Ihle
A search
the2001).
literature
is a growing body of literature
subtype
(Chen et al.in
2016).
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